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© Research
Publication : Critical care medicine

Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients

Team: Archived: Cytokines and Inflammation
Member: Jean-Marc Cavaillon
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Critical care medicine - 01 Sep 2006

Adib-Conquy M, Adrie C, Fitting C, Gattolliat O, Beyaert R, Cavaillon JM

Link to Pubmed [PMID] – 16850005

Crit. Care Med. 2006 Sep;34(9):2377-85

Immune status is altered during systemic inflammatory response syndrome and sepsis. Reduced ex vivo tumor necrosis factor production has been regularly reported with lipopolysaccharide-activated monocytes. In this study, we addressed the specificity of this hyporeactivity and investigated some of the possible associated mechanistic events.