Link to Pubmed [PMID] – 38663181
Link to DOI – 10.1016/j.mib.2024.102477
Curr Opin Microbiol 2024 Jun; 79(): 102477
Apicomplexan and trypanosomatid parasites have evolved a wide range of post-transcriptional processes that allow them to replicate, differentiate, and transmit within and among multiple different tissue, host, and vector environments. In this review, we highlight the recent advances that point toward the regulatory potential of RNA modifications in mediating these processes on the coding and noncoding transcriptome throughout the life cycle of protozoan parasites. We discuss the recent technical advancements enabling the study of the ‘epitranscriptome’ and how parasites evolved RNA modification-mediated mechanisms adapted to their unique lifestyles.