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© Jacob SEELER & Anne DEJEAN, Institut Pasteur
Immunostaining of PML nuclear bodies involved in acute promyelocytic leukemia
Publication : Molecular cancer

TP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma

Team: Nuclear Organization and Oncogenesis
Member: Anne Dejean
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular cancer - 02 Apr 2015

Rebbani K, Marchio A, Ezzikouri S, Afifi R, Kandil M, Bahri O, Triki H, Essaid El Feydi A, Dejean A, Benjelloun S, Pineau P

Link to Pubmed [PMID] – 25889455

Mol. Cancer 2015;14(1):74

Hepatocellular carcinoma (HCC) is characterized by widespread epidemiological and molecular heterogeneity. Previous work showed that in the western part of North Africa, a region of low incidence of HCC, mutations are scarce for this tumor type. As epigenetic changes are considered possible surrogates to mutations in human cancers, we decided, thus, to characterize DNA methylation in HCC from North-African patients.