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© Research
Publication : The Journal of general physiology

To be, or not to be two sites: that is the question about LeuT substrate binding

Team: Archived: Membrane protein mechanisms
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of general physiology - 12 Sep 2011

Reyes N, Tavoulari S

Link to Pubmed [PMID] – 21911482

J. Gen. Physiol. 2011 Oct;138(4):467-71

Transport proteins of the neurotransmitter sodium symporter (NSS) family regulate the extracellular concentration of several neurotransmitters in the central nervous system. The only member of this family for which atomic-resolution structural data are available is the prokaryotic homologue LeuT. This protein has been used as a model system to study the molecular mechanism of transport of the NSS family. In this Journal Club, we discuss two strikingly different LeuT transport mechanisms: one involving a single high-affinity substrate binding site and one recently proposed alternative involving two high-affinity substrate binding sites that are allosterically coupled.