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© Research
Publication : Developmental biology

Three linked myosin heavy chain genes clustered within 370 kb of each other show independent transcriptional and post-transcriptional regulation during differentiation of a mouse muscle cell line.

Team: Malaria Infection & Immunity
Team: Malaria Parasite Biology and Vaccines
Member: Margaret Buckingham
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Developmental biology - 01 Jan 1991

Cox RD, Weydert A, Barlow D, Buckingham ME

Link to Pubmed [PMID] – 1985022

Dev Biol 1991 Jan; 143(1): 36-43

We have examined myosin heavy chain gene transcription in the mouse muscle cell line C2/7 under different culture conditions. Gene-specific probes for embryonic (MHCemb), perinatal (MHCpn), and adult (MHCIIB) MHC sequences were used in nuclear run-on experiments, and transcriptional levels compared with cytoplasmic RNA accumulation of the transcripts during muscle cell differentiation. Transcripts are not detectable in myoblasts. These three MHC genes are physically linked within 370 kb of each other. However, they are not activated coordinately, but show independent transcriptional regulation as muscle cells differentiate into myotubes and as myotubes mature in culture. Post-transcriptional mechanisms also regulate cytoplasmic RNA accumulation of these MHC genes.