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© Research
Publication : Fungal genetics and biology : FG & B

The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence

Team: Archived: Aspergillus
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Fungal genetics and biology : FG & B - 12 Mar 2014

Muszkieta L, Carrion Sde J, Robinet P, Beau R, Elbim C, Pearlman E, Latgé JP

Link to Pubmed [PMID] – 24614084

Fungal Genet. Biol. 2014 May;66:79-85

Protein phosphatases Z that are unique to the fungal kingdom have been associated to resistance to high salt concentration, cell wall integrity, cell cycle regulation, and oxidative stress in fungi. In Aspergillus fumigatus, it was shown that PHZA is under the control of the transcription factor Skn7 and is only involved in the control of the oxidative stress. Accordingly, the ΔphzA mutant showed a defect in virulence in an experimental model of corneal infection in immunocompetent animals and that the impact on susceptibility to cell wall drugs is only secondary.