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© Research
Publication : Journal of molecular microbiology and biotechnology

The FtsK family of DNA translocases finds the ends of circles

Member: Florian Fournès
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of molecular microbiology and biotechnology - 17 Feb 2015

Crozat E, Rousseau P, Fournes F, Cornet F

Link to Pubmed [PMID] – 25732341

J. Mol. Microbiol. Biotechnol. 2014;24(5-6):396-408

A global view of bacterial chromosome choreography during the cell cycle is emerging, highlighting as a next challenge the description of the molecular mechanisms and factors involved. Here, we review one such factor, the FtsK family of DNA translocases. FtsK is a powerful and fast translocase that reads chromosome polarity. It couples segregation of the chromosome with cell division and controls the last steps of segregation in time and space. The second model protein of the family SpoIIIE acts in the transfer of the Bacillus subtilis chromosome during sporulation. This review focuses on the molecular mechanisms used by FtsK and SpoIIIE to segregate chromosomes with emphasis on the latest advances and open questions.