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© Research
Publication : Progress in neuro-psychopharmacology & biological psychiatry

The association of β-arrestin2 polymorphisms with response to antidepressant treatment in depressed patients

Member: Anne-Cecile Petit
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Progress in neuro-psychopharmacology & biological psychiatry - 16 Mar 2018

Petit AC, El Asmar K, David DJ, Gardier AM, Becquemont L, Fève B, Verstuyft C, Corruble E

Link to Pubmed [PMID] – 29031912

Prog. Neuropsychopharmacol. Biol. Psychiatry 2018 Feb;81:74-79

The study of genetic polymorphisms involved in antidepressants (AD) response is essential to provide a personalized medicine approach in the field of depression. β-arrestin 2 (ARRB2) is a candidate gene in the pharmacogenetics of AD as it is involved in the signaling cascade downstream of numerous neurotransmitter receptors. We investigated the association between five ARRB2 single nucleotide polymorphisms (SNPs): rs1045280, rs2036657, rs4790694, rs3786047 and rs452246, and response to AD treatment in a sample of 569 patients with a major depressive episode treated for 6months. We show that GG/GT patients for rs4522461 (n=534) and AA/AC patients for rs4790694 (n=244) have a lower response to AD than other genotype groups (HDRS score of 10.9 vs 8.0 after 6months, multivariate analysis: p=0.03; 12.2 vs 9.6, p=0.02, respectively). These data provide additional evidence that β-arrestin 2 is a regulator of intracellular signal transduction processes involved in AD treatment.