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© Research
Publication : Antimicrobial agents and chemotherapy

Successful Treatment of sp. Osteomyelitis by Conservative Surgery and Intradiaphyseal Incorporation of Amphotericin B Cement Beads

Reference Center: Invasive Mycoses and Antifungals
Member: Dea Garcia-Hermoso
Member: Olivier Lortholary
Member: Fanny Lanternier
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 21 Dec 2018

Parize P, Mamez AC, Garcia-Hermoso D, Dumaine V, Poirée S, Kauffmann-Lacroix C, Jullien V, Lortholary O, Lanternier F

Link to Pubmed [PMID] – 30373790

Antimicrob. Agents Chemother. 2019 Jan;63(1)

Osteoarticular mucormycosis cases are quite rare and challenging infections that are mostly due to direct inoculation during traumatic injury among immunocompetent patients. Classic management includes a combination of aggressive surgical debridement, which may lead to amputation, and long-term systemic liposomal amphotericin B therapy. This article describes the successful treatment of sp. osteomyelitis in a patient with diabetes mellitus, using a combination of systemic antifungal therapy and conservative surgery with insertion of amphotericin-impregnated cement beads.