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© Research
Publication : Trends in neurosciences

Structural Identification of the Nicotinic Receptor Ion Channel

Member: Jean-Pierre Changeux
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in neurosciences - 01 Feb 2018

Changeux JP

Link to Pubmed [PMID] – 29405928

Trends Neurosci. 2018 02;41(2):67-70

The structural identification of the cationic channel of the acetylcholine nicotinic receptor involved its biochemical tagging by channel blockers, followed by site-directed mutagenesis analyses reported in two papers in 1988. The ion channel was demonstrated to be lined by the transmembrane segment MII, in which the binding sites of channel blockers are “framed” by anionic rings.