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© Research
Publication : Nature communications

Stress-induced formation of cell wall-deficient cells in filamentous actinomycetes.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 04 Dec 2018

Ramijan K, Ultee E, Willemse J, Zhang Z, Wondergem JAJ, van der Meij A, Heinrich D, Briegel A, van Wezel GP, Claessen D

Link to Pubmed [PMID] – 30514921

Link to DOI – 10.1038/s41467-018-07560-9

Nat Commun 2018 Dec; 9(1): 5164

The cell wall is a shape-defining structure that envelopes almost all bacteria and protects them from environmental stresses. Bacteria can be forced to grow without a cell wall under certain conditions that interfere with cell wall synthesis, but the relevance of these wall-less cells (known as L-forms) is unclear. Here, we show that several species of filamentous actinomycetes have a natural ability to generate wall-deficient cells in response to hyperosmotic stress, which we call S-cells. This wall-deficient state is transient, as S-cells are able to switch to the normal mycelial mode of growth. However, prolonged exposure of S-cells to hyperosmotic stress yields variants that are able to proliferate indefinitely without their cell wall, similarly to L-forms. We propose that formation of wall-deficient cells in actinomycetes may serve as an adaptation to osmotic stress.