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© Research
Publication : Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

Stable recovery from HCV in HIV-HCV co-infection under antiretroviral therapy

Team: Archived: Immunobiology of Dendritic Cells
Member:
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 19 Jul 2007

Zeitoun JD, Mallet V, Chaix ML, Viard JP, Blanche S, Pol S

Link to Pubmed [PMID] – 17658294

J. Clin. Virol. 2007 Sep;40(1):71-3

Co-infection by the hepatitis C virus (HCV) and the human immunodeficiency virus (HIV) is common. HIV co-infection worsens the course of HCV infection, particularly in patients with low CD4-cell count, enhancing the need to cancel HCV replication in HIV-infected patients. We report a case of spontaneous recovery of chronic HCV-infection in a HCV-HIV co-infected hemophiliac with the introduction of combined antiretroviral therapy and immune restoration. Retrospective analysis of frozen blood samples showed that a decrease in HCV-RNA in parallel with the increase of CD4 and CD8-cell counts, accompanied by a peak of transaminases. The respective effect of immune restoration and of high doses of ritonavir are discussed.