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© Charles Dauguet
Virus VIH-1 (HIV-1), agent du sida, à la surface d'un lymphocyte. Image colorisée.
Publication : AIDS (London, England)

Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium falciparum

Team: Group: MISTIC
Team: Archived: Regulation of Retroviral Infections
Team: Ecology and Emergence of Arthropod-borne Pathogens
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in AIDS (London, England) - 30 Mar 2008

Ayouba A, Badaut C, Kfutwah A, Cannou C, Juillerat A, Gangnard S, Behr C, Mercereau-Puijalon O, Bentley GA, Barré-Sinoussi F, Menu E

Link to Pubmed [PMID] – 18356610

AIDS 2008 Mar;22(6):785-7

Epidemiological data point to an increased risk of HIV-1 mother-to-child transmission in pregnant women with malaria, by unknown mechanisms. We show here that surface binding of a recombinant Plasmodium falciparum adhesin to chondroitin sulphate A proteoglycans increases HIV-1 replication in the human placental cell line BeWo, probably by a P. falciparum adhesin-induced long-terminal repeat-driven TNF-alpha stimulation. This suggests that placental malaria could increase the risk of HIV-1 transmission in utero.