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© Research
Publication : Nanoscale

Single KTP nanocrystals as second-harmonic generation biolabels in cortical neurons

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Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nanoscale - 21 Sep 2013

Mayer L, Slablab A, Dantelle G, Jacques V, Lepagnol-Bestel AM, Perruchas S, Spinicelli P, Thomas A, Chauvat D, Simonneau M, Gacoin T, Roch JF

Link to Pubmed [PMID] – 23852161

Nanoscale 2013 Sep;5(18):8466-71

We report an efficient colloidal synthesis of KTiOPO4 (KTP) nanocrystals with excellent crystallinity and the direct observation of optical second-harmonic generation (SHG) from discrete KTP nanocrystals in neurons cultured from mammalian brain cortex. Direct internalization and monitoring of these nanoparticles was successfully achieved without limitations from cytotoxicity, bleaching and blinking emission.