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© Research
Publication : Retrovirology

Reduced CD4 T cell activation and in vitro susceptibility to HIV-1 infection in exposed uninfected Central Africans

Team: Epidemiology of Emerging Diseases
Team: Archived: Group: Daniel Scott-Algara
Team: Archived: Regulation of Retroviral Infections
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Retrovirology - 22 Jun 2006

Bégaud E, Chartier L, Marechal V, Ipero J, Léal J, Versmisse P, Breton G, Fontanet A, Capoulade-Metay C, Fleury H, Barré-Sinoussi F, Scott-Algara D, Pancino G

Link to Pubmed [PMID] – 16792805

Retrovirology 2006;3:35

Environmentally driven immune activation was suggested to contribute to high rates of HIV-1 infection in Africa. We report here a study of immune activation markers and susceptibility to HIV-1 infection in vitro of forty-five highly exposed uninfected partners (EUs) of HIV-1 infected individuals in Central African Republic, in comparison with forty-four low-risk blood donors (UCs).