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© Research
Publication : Virology

Rapid test for hepatitis B core-related antigen to identify people living with hepatitis B having high viral load in Cameroon.

Team: Elimination of viral hepatitis
Team: Epidemiology of Emerging Diseases
Network: Pasteur Center in Cameroon
Member: Yusuke Shimakawa
Member: Jeanne Perpétue Vincent
Member: Richard Njouom
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Virology - 01 Jan 2025

Njouom R, Ndiaye A, Modiyinji AF, Lissock F, Vincent JP, Baba M, Yamamoto N, Kaneko A, Aoyagi K, Hashimoto N, Nagai M, Ichikawa M, Miura T, Sugiura W, Tanaka Y, Shimakawa Y

Link to Pubmed [PMID] – 39626609

Link to DOI – 10.1016/j.virol.2024.110316

Virology 2025 Jan; 602(): 110316

This study presents a retrospective assessment of the diagnostic performance of the newly developed hepatitis B core-related antigen rapid diagnostic test (HBcrAg-RDT) in detecting plasma samples with elevated hepatitis B virus (HBV) DNA levels (≥200,000 IU/ml) in Yaoundé, Cameroon. Samples were collected consecutively from treatment-naïve adults living with HBV between January 1, 2021, and June 30, 2023. Analyzing 146 samples from participants with a median age of 36 years, the HBcrAg-RDT exhibited a sensitivity of 97.5% (95% CI: 86.8-99.9) and a specificity of 77.4% (68.2-84.9) when compared to real-time PCR as the reference standard. These findings suggest that HBcrAg-RDT holds promise as a valuable point-of-care tool for diagnosing high HBV DNA levels, particularly in resource-limited settings. Further research will refine its practicality and effectiveness.