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© Research
Publication : Antimicrobial agents and chemotherapy

Raltegravir concentrations in the genital tract of HIV-1-infected women treated with a raltegravir-containing regimen (DIVA 01 study)

Team: Archived: Molecular Retrovirology
Member:
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 28 Mar 2011

Clavel C, Peytavin G, Tubiana R, Soulié C, Crenn-Hebert C, Heard I, Bissuel F, Ichou H, Ferreira C, Katlama C, Marcelin AG, Mandelbrot L

Link to Pubmed [PMID] – 21444705

Antimicrob. Agents Chemother. 2011 Jun;55(6):3018-21

We studied the penetration of raltegravir and HIV shedding in the genital tract among 14 HIV-1-infected women receiving a raltegravir-containing regimen who had <40 copies/ml blood plasma (BP) HIV RNA. None of the cervicovaginal fluid (CVF) samples showed detectable HIV RNA. Median raltegravir concentrations were 235 ng/ml in BP and 93 ng/ml in CVF, with a CVF/BP ratio of approximately 2.3. This good penetration of raltegravir may contribute to the control of viral replication in the female genital tract.