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© Research
Publication : Archives of microbiology

Pseudomonas fluorescens can induce and divert the human β-defensin-2 secretion in intestinal epithelial cells to enhance its virulence

Team: Microenvironment and Immunity
Member:
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Archives of microbiology - 10 Jan 2013

Madi A, Alnabhani Z, Leneveu C, Mijouin L, Feuilloley M, Connil N

Link to Pubmed [PMID] – 23306900

Arch. Microbiol. 2013 Mar;195(3):189-95

The effect of intestinal molecules produced by the host on the virulence of Pseudomonas fluorescens is poorly documented. In the present work, we evaluated the secretion of human β-defensin-2 (hBD-2) by enterocytes after infection with P. fluorescens (a species previously suggested to be involved in inflammatory bowel disease) and investigated the effect of this host-defense peptide on the bacterial virulence. The results showed that P. fluorescens can induce hBD-2 production in Caco-2/TC7 cells via P38 and ERK MAPK-dependent pathways. Surprisingly, the exposure of P. fluorescens to low doses of the antimicrobial peptide was found to enhance its cytotoxic and proinflammatory effects suggesting a potential feedback mechanism in the dialog between bacteria and the host.