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© Research
Publication : PloS one

Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages

Member: Brigitte Gicquel
Member: Ludovic Tailleux
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 02 Jan 2008

Tailleux L, Waddell SJ, Pelizzola M, Mortellaro A, Withers M, Tanne A, Castagnoli PR, Gicquel B, Stoker NG, Butcher PD, Foti M, Neyrolles O

Link to Pubmed [PMID] – 18167562

PLoS ONE 2008;3(1):e1403

Transcriptional profiling using microarrays provides a unique opportunity to decipher host pathogen cross-talk on the global level. Here, for the first time, we have been able to investigate gene expression changes in both Mycobacterium tuberculosis, a major human pathogen, and its human host cells, macrophages and dendritic cells.