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© Research
Publication : Annals of translational medicine

Predicting Wolbachia potential to knock down dengue virus transmission

Team: Insect-Virus Interactions
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annals of translational medicine - 01 Nov 2015

Lambrechts L

Link to Pubmed [PMID] – 26697448

Ann Transl Med 2015 Nov;3(19):288

Releasing mosquitoes infected with the intracellular bacteria Wolbachia is a candidate strategy for dengue control that has recently advanced to field-testing. A critical next step is to evaluate the impact of this strategy on dengue epidemiology. A recent study by Ferguson and colleagues presents a mathematical framework to predict the likely effect of mosquitoes carrying Wolbachia on dengue virus transmission. Fitting the mathematical model to empirical data obtained with Wolbachia-infected mosquitoes experimentally challenged with viremic blood from dengue patients indicates that dengue virus transmission could be reduced by a degree that would have a significant impact on public health.