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© Research
Publication : Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie

[Potentiation of the antitumoral effect of electrochemotherapy by immunotherapy with allogeneic cells producing interleukin 2]

Team: Ecology and Emergence of Arthropod-borne Pathogens
Member: Claude Roth
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie - 01 Jan 1992

Mir LM, Roth C, Orlowski S, Belehradek J, Fradelizi D, Paoletti C, Kourilsky P

Link to Pubmed [PMID] – 1381659

C. R. Acad. Sci. III, Sci. Vie 1992;314(12):539-44

Electrochemotherapy (ECT) is a new antitumour treatment which consists of delivering electric pulses to the tumour a few minutes after an intravenous injection of bleomycin. The antitumour efficacy of ECT is increased by local injections of interleukin 2 (IL2) in the oedema which appears at the site of the treated tumours. We have shown that tumour cells inoculated in syngeneic mice are rejected if IL2 secreting allo- or xenogeneic cells are co-injected with tumour cells. We report here the large increase of ECT therapeutical efficacy when allogeneic cells secreting IL2 are injected into the peri-tumoural oedema.