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© Research
Publication : Infection and immunity

Polymorphism of repeated regions of pertactin in Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica

Reference Center: Whooping Cough and other Bordetella infections
Member: Nicole Guiso
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection and immunity - 01 Aug 2000

Boursaux-Eude C, Guiso N

Link to Pubmed [PMID] – 10899896

Infect. Immun. 2000 Aug;68(8):4815-7

Pertactin is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica that induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed that B. parapertussis pertactin is invariant, whereas B. pertussis pertactin varies mostly in region I and B. bronchiseptica pertactin varies in both repeated regions I and II, but mostly in region II. These differences may result from specific characteristics of these Bordetella species.