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  • Director of Center
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© Research
Publication : European journal of immunology

Normal serum immunoglobulins influence the numbers of bone marrow pre-B and B cells

Member: Antonio Freitas
Member: François Huetz
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 May 1991

Sundblad A, Marcos M, Huetz F, Freitas A, Heusser C, Portnoï D, Coutinho A

Link to Pubmed [PMID] – 1828029

Eur. J. Immunol. 1991 May;21(5):1155-61

The homeostatic mechanisms controlling B lymphocyte output from bone marrow are not well understood. The present experiments evaluated putative influences of circulating immunoglobulins (Ig) on bone marrow (BM) pre-B and B cell populations. Injections into normal mice of Ig isolated from normal mouse serum, resulted in a dose-dependent and reversible reduction in numbers of BM B lineage cells, in particular of small B220+ surface IgM- cells. Maximal effects were observed upon injection of isologous polyclonal Ig and were independent of mature T cells. These results suggest a feedback modulation of peripheral Ig on cellular activities in BM B lineage compartments, mediated by mechanisms that seem to involve the variable regions of the Ig molecule.