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© Research
Publication : Chemical communications (Cambridge, England)

NMR reveals the interplay between SilE and SilB model peptides in the context of silver resistance.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Chemical communications (Cambridge, England) - 11 Sep 2021

Babel L, Nguyen MH, Mittelheisser C, Martin M, Fromm KM, Walker O, Hologne M

Link to Pubmed [PMID] – 34396382

Link to DOI – 10.1039/d1cc02597j

Chem Commun (Camb) 2021 Sep; 57(70): 8726-8729

SilE and SilB are both proteins involved in the silver efflux pump found in Gram-negative bacteria such as S. typhimurium. Using model peptides along with NMR and CD experiments, we show how SilE may store silver ions prior to delivery and we hypothesize for the first time the interplay between SilB and SilE.