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© Research
Publication : Journal of molecular biology

New lessons from random X-chromosome inactivation in the mouse

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of molecular biology - 15 Feb 2011

Clerc P, Avner P

Link to Pubmed [PMID] – 21329697

J. Mol. Biol. 2011 May;409(1):62-9

X-chromosome inactivation (XCI) ensures dosage compensation in mammals. Random XCI is a process where a single X chromosome is silenced in each cell of the epiblast of mouse female embryos. Operating at the level of an entire chromosome, XCI is a major paradigm for epigenetic processes. Here we review the most recent discoveries concerning the role of long noncoding RNAs, pluripotency factors, and chromosome structure in random XCI.