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© Research
Publication : Gastroenterology

Neutrophil migration during liver injury is under nucleotide-binding oligomerization domain 1 control

Member: Philippe Sansonetti
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Gastroenterology - 21 Dec 2009

Dharancy S, Body-Malapel M, Louvet A, Berrebi D, Gantier E, Gosset P, Viala J, Hollebecque A, Moreno C, Philpott DJ, Girardin SE, Sansonetti PJ, Desreumaux P, Mathurin P, Dubuquoy L

Link to Pubmed [PMID] – 20026116

Gastroenterology 2010 Apr;138(4):1546-56, 1556.e1-5

A more complete understanding of the mechanisms involved in pathogen-associated molecular pattern signaling is crucial in the setting of liver injury. In intestinal diseases, nucleotide-binding oligomerization domain 1 (NOD1), a receptor for bacteria, appears to regulate cross-talk between innate and adaptive immunity, involving polymorphonuclear neutrophils (PMNs). Our aim was to explore the role of NOD1 in PMN-induced liver injury.