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© Research
Publication : Current opinion in HIV and AIDS

Natural killer cells, dendritic cells, and the alarmin high-mobility group box 1 protein: a dangerous trio in HIV-1 infection?

Team: Archived: Innate Immunity and Viruses
Member: Marie-Lise Gougeon
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in HIV and AIDS - 01 Sep 2011

Gougeon ML, Bras M

Link to Pubmed [PMID] – 21825870

Curr Opin HIV AIDS 2011 Sep;6(5):364-72

Natural killer (NK) cells promote antiviral immunity by producing proinflammatory cytokines and by lysing infected cells. In addition, NK cells can modulate dendritic cell functions. NK-dendritic cell crosstalk results in activation of both cell types, with dendritic cells promoting NK-cell activity and NK cells inducing further maturation of dendritic cells. Here we review the recent evidence suggesting that NK-dendritic cell crosstalk is disrupted during HIV-1 infection and we discuss the consequences on HIV persistence in dendritic cells.