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© Research
Publication : Trends in biochemical sciences

Molecular architecture of bacterial type IV secretion systems

Team: Archived: Structural Biology of Bacterial Secretion
Member:
Scientific Fields
Diseases
Organisms
Applications
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Published in Trends in biochemical sciences - 10 Jul 2010

Waksman G, Fronzes R

Link to Pubmed [PMID] – 20621482

Trends Biochem. Sci. 2010 Dec;35(12):691-8

In Gram-negative bacteria, type IV secretion (T4S) systems form ATP-powered complexes that span the entire cellular envelope and secrete a wide variety of substrates from single proteins to protein-protein and protein-DNA complexes. Recent structural data, namely the electron microscopy structure of the T4S core complex and the atomic-resolution structure of its outer-membrane pore, have profoundly altered our understanding of T4S architecture and mechanisms.