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© Research
Publication : Journal of gastrointestinal cancer

Mitochondrial DNA Copy Number Variations in Gastrointestinal Tract Cancers: Potential Players.

Team: Group: Infection, Genotoxicity and Cancer
Member: Eliette Touati
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of gastrointestinal cancer - 01 Sep 2022

Alikhani M, Touati E, Karimipoor M, Vosough M, Mohammadi M

Link to Pubmed [PMID] – 34486088

Link to DOI – 10.1007/s12029-021-00707-w

J Gastrointest Cancer 2022 Sep; 53(3): 770-781

Alterations of mitochondria have been linked to several cancers. Also, the mitochondrial DNA copy number (mtDNA-CN) is altered in various cancers, including gastrointestinal tract (GIT) cancers, and several research groups have investigated its potential as a cancer biomarker. However, the exact causes of mtDNA-CN variations are not yet revealed. This review discussed the conceivable players in this scheme, including reactive oxygen species (ROS), mtDNA genetic variations, DNA methylation, telomere length, autophagy, immune system activation, aging, and infections, and discussed their possible impact in the initiation and progression of cancer. By further exploring such mechanisms, mtDNA-CN variations may be effectively utilized as cancer biomarkers and provide grounds for developing novel cancer therapeutic agents.