Link to Pubmed [PMID] – 21035752
Link to DOI – 10.1016/j.cmet.2010.10.007
Cell Metab 2010 Nov; 12(5): 425-6
Deregulation of microRNAs in dystrophic muscle highlights their importance in muscle homeostasis. A recent study in Cell Metabolism (Cacchiarelli et al., 2010) shows that the presence of functional dystrophin is required for NO-dependent nitrosylation of the HDAC2 repressor and subsequent activation of a group of microRNAs required for muscle function.