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© Research
Publication : The Journal of general virology

MBT/Pas mouse: a relevant model for the evaluation of Rift Valley fever vaccines

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of general virology - 18 Apr 2012

Ayari-Fakhfakh E, do Valle TZ, Guillemot L, Panthier JJ, Bouloy M, Ghram A, Albina E, Cêtre-Sossah C

Link to Pubmed [PMID] – 22513390

J. Gen. Virol. 2012 Jul;93(Pt 7):1456-64

Currently, there are no worldwide licensed vaccines for Rift Valley fever (RVF) that are both safe and effective. Development and evaluation of vaccines, diagnostics and treatments depend on the availability of appropriate animal models. Animal models are also necessary to understand the basic pathobiology of infection. Here, we report the use of an inbred MBT/Pas mouse model that consistently reproduces RVF disease and serves our purpose for testing the efficacy of vaccine candidates; an attenuated Rift Valley fever virus (RVFV) and a recombinant RVFV-capripoxvirus. We show that this model is relevant for vaccine testing.