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© Research
Publication : Critical care medicine

Lung microenvironment contributes to the resistance of alveolar macrophages to develop tolerance to endotoxin*

Team: Archived: Cytokines and Inflammation
Member: Jean-Marc Cavaillon
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Critical care medicine - 01 Nov 2012

Philippart F, Fitting C, Cavaillon JM

Link to Pubmed [PMID] – 22878679

Crit. Care Med. 2012 Nov;40(11):2987-96

Endotoxin tolerance corresponds to reprogramming of mononuclear phagocytes after iterative encounters with toll-like receptor agonists aimed to dampen the inflammatory response. We investigated why this phenomenon cannot be observed with murine alveolar macrophages.