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© Research
Publication : Antimicrobial agents and chemotherapy

Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure

Member: Laurence Weiss
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 10 Aug 2009

Fransen S, Karmochkine M, Huang W, Weiss L, Petropoulos CJ, Charpentier C

Link to Pubmed [PMID] – 19667293

Antimicrob. Agents Chemother. 2009 Oct;53(10):4522-4

We characterized the raltegravir (RAL) susceptibility and the integrase (IN)-mediated replication capacity (RC) of RAL-resistant human immunodeficiency virus type 1 from two patients experiencing virologic failure during continuous RAL salvage therapy. The following two distinct outcomes were observed: (i) the selective outgrowth of virus with high-level RAL resistance and high IN-mediated RC leading to significant viral load rebound and (ii) the selection of virus with a slight reduction in RAL susceptibility and low IN-mediated RC resulting in sustained low-level viremia.