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© Research
Publication : Vaccine

Long-term humoral and cell-mediated immunity after acellular pertussis vaccination compares favourably with whole-cell vaccines 6 years after booster vaccination in the second year of life

Reference Center: Whooping Cough and other Bordetella infections
Member: Nicole Guiso
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Vaccine - 07 Nov 2006

Guiso N, Njamkepo E, Vié le Sage F, Zepp F, Meyer CU, Abitbol V, Clyti N, Chevallier S

Link to Pubmed [PMID] – 17134795

Vaccine 2007 Feb;25(8):1390-7

Humoral and cell-mediated immune responses (CMI) were evaluated in subjects 3 and 6 years after primary and booster vaccination with either three-component acellular (Pa) or whole-cell (Pw) vaccines. Low anti-pertussis toxin (PT) antibody levels confirmed the absence of pertussis disease, consistent with ongoing protection. Anti-pertactin (PRN) antibodies, remained at higher levels in Pa-vaccinated subjects. At year 6, CMI responses continued to be present and were higher in Pa-vaccinated than Pw-vaccinated subjects. Long-term protection with Pa vaccines can be expected to be at least as good as that provided by efficacious Pw vaccines.