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© Research
Publication : Cell stem cell

lncRNA-Encoded Polypeptide SPAR(s) with mTORC1 to Regulate Skeletal Muscle Regeneration

Team: Stem Cells And Development
Member: Shahragim Tajbakhsh
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell stem cell - 06 Apr 2017

Tajbakhsh S

Link to Pubmed [PMID] – 28388426

Cell Stem Cell 2017 Apr;20(4):428-430

Although prematurely baptized as non-coding, some lncRNAs encode polypeptides with regulatory functions that are implicated in various biological processes. Matsumoto et al. (2017) recently report in Nature that LINC00961 generates SPAR polypeptide that acts via the lysosome to suppress amino-acid-mediated mTORC1 activity, thereby modulating skeletal muscle regenerative response following injury.