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© Research
Publication : Vaccine

Intranasal murine model of Bordetella pertussis infection. I. Prediction of protection in human infants by acellular vaccines

Reference Center: Whooping Cough and other Bordetella infections
Member: Nicole Guiso
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Vaccine - 14 May 1999

Guiso N, Capiau C, Carletti G, Poolman J, Hauser P

Link to Pubmed [PMID] – 10392618

Vaccine 1999 May;17(19):2366-76

Bicomponent, tricomponent and pertactin DTPa vaccines were tested in sublethal aerosol, and lethal and sublethal intranasal murine Bordetella pertussis respiratory challenge models. Pertactin and bicomponent vaccines induced protective immunity against lethality but with little or no bacterial clearance. Intranasal challenge discriminated in a reproducible, statistically significant manner between the efficacies of bicomponent and tricomponent DTPa, in agreement with clinical trial data. This discrimination was not observed in the aerosol challenge. Pertactin had a synergistic effect with bicomponent DTPa. Intranasal challenge may be useful as part of the preclinical evaluation of new acellular pertussis formulations or DTPa-based combinations.