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© Research
Publication : Haematologica

Interleukin 2 and mitogen driven proliferation in human peripheral mononuclear cells: a kinetic analysis

Team: Archived: Group: Elisabetta Bianchi
Team: Immunoregulation
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Haematologica - 01 Jul 1989

Ferrero E, Manfredi A, Bianchi E, Schönheit A, Sabbadini MG, Rugarli C

Link to Pubmed [PMID] – 2507408

Haematologica 1989 Jul-Aug;74(4):355-8

The role of the T lymphocyte growth factor, interleukin 2 (IL2), on human lymphocyte proliferation was investigated. The results define the extent and the chronological sequence of IL2 effects on unstimulated mononuclear cells and on an activated population enriched in IL2 receptor positive cells. Important differences were observed in the proliferative response to the mitogen PHA when the IL2 concentration in the culture medium was varied. The data suggest that IL2 concentration is critical in the responsiveness to a mitogenic stimulus.