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© Research
Publication : Antimicrobial agents and chemotherapy

In vitro interaction of flucytosine with conventional and new antifungals against Cryptococcus neoformans clinical isolates

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 01 Oct 2003

Schwarz P, Dromer F, Lortholary O, Dannaoui E

Link to Pubmed [PMID] – 14506059

Antimicrob. Agents Chemother. 2003 Oct;47(10):3361-4

Combinations of flucytosine with conventional and new antifungals were evaluated in vitro against 30 clinical isolates of Cryptococcus neoformans. Synergy determined by checkerboard analysis was observed with combinations of fluconazole, itraconazole, voriconazole, amphotericin B, and caspofungin with flucytosine against 77, 60, 80, 77, and 67% of the isolates, respectively. Antagonism was never observed. Killing curves showed indifferent interactions between triazoles and flucytosine and synergy between amphotericin B and flucytosine.