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© Research
Publication : Open forum infectious diseases

IgG Antibody Responses Are Preferential Compared With IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection.

Team: Infectious Disease Epidemiology and Analytics
Member: Michael White
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Open forum infectious diseases - 01 Jun 2021

Longley RJ, White MT, Brewster J, Liu ZSJ, Bourke C, Takashima E, Harbers M, Tham WH, Healer J, Chitnis CE, Monteiro W, Lacerda M, Sattabongkot J, Tsuboi T, Mueller I,

Link to Pubmed [PMID] – 34159216

Link to DOI – 10.1093/ofid/ofab228

Open Forum Infect Dis 2021 Jun; 8(6): ofab228

To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.