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© Research
Publication : PloS one

I223R mutation in influenza A(H1N1)pdm09 neuraminidase confers reduced susceptibility to oseltamivir and zanamivir and enhanced resistance with H275Y

Team: Archived: Molecular Genetics of RNA Viruses
Member: Vincent Enouf
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 24 Aug 2012

LeGoff J, Rousset D, Abou-Jaoudé G, Scemla A, Ribaud P, Mercier-Delarue S, Caro V, Enouf V, Simon F, Molina JM, van der Werf S

Link to Pubmed [PMID] – 22936969

PLoS ONE 2012;7(8):e37095

Resistance of pandemic A(H1N1)2009 (H1N1pdm09) virus to neuraminidase inhibitors (NAIs) has remained limited. A new mutation I223R in the neuraminidase (NA) of H1N1pdm09 virus has been reported along with H275Y in immunocompromised patients. The aim of this study was to determine the impact of I223R on oseltamivir and zanamivir susceptibility.