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© Research
Publication : Biochemical and biophysical research communications

Human epidermis is a novel site of phospholipase B expression

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biochemical and biophysical research communications - 12 Jul 2002

Maury E, Prévost MC, Nauze M, Redoulès D, Tarroux R, Charvéron M, Salles JP, Perret B, Chap H, Gassama-Diagne A

Link to Pubmed [PMID] – 12150957

Biochem. Biophys. Res. Commun. 2002 Jul;295(2):362-9

Phospholipase B (PLB) is an enzyme that displays both phospholipase A(2) and lysophospholipase activities. Analysis of human epidermis homogenates indicated the presence of a 97 kDa PLB protein, as well as a phospholipase A(2) activity, both being enriched in the soluble fraction. Immunolabelling and in situ hybridization experiments showed that this enzyme is expressed in the different layers of epidermis with an accumulation at the dermo-epidermis junction. RT-PCR data indicated that PLB is specifically expressed in natural and reconstructed epidermis. By 3′-RACE-PCR and screening of human genome databases, we obtained a 3600 bp cDNA coding for human PLB highly homologous to already described intestinal brush border PLBs. These data led us to conclude that the soluble PLB corresponds to a proteolytic cleavage of the membrane anchored protein. Altogether, our results provide the first characterization of human PLB which should play an important role in epidermal barrier function.