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© A-M. Pais-Correia, M-I. Thoulouze, A. Alcover, A. Gessain
Mise en évidence de structures de type "biofilm ", formées par le rétrovirus HTLV-1 générés par des cellules infectées (cellules du haut), qui ont été transmis à un autre lymphocyte (cellule du bas). Micrographie en microscopie électronique à balayage. Image colorisée.
Publication : Retrovirology

HTLV-1-infected CD4+ T-cells display alternative exon usages that culminate in adult T-cell leukemia

Team: Oncogenic Virus Epidemiology and Pathophysiology
Member: Antoine Gessain
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Retrovirology - 18 Dec 2014

Thénoz M, Vernin C, Mortada H, Karam M, Pinatel C, Gessain A, Webb TR, Auboeuf D, Wattel E, Mortreux F

Link to Pubmed [PMID] – 25519886

Retrovirology 2014;11:119

Reprogramming cellular gene transcription sustains HTLV-1 viral persistence that ultimately leads to the development of adult T-cell leukemia/lymphoma (ATLL). We hypothesized that besides these quantitative transcriptional effects, HTLV-1 qualitatively modifies the pattern of cellular gene expression.