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© Research
Publication : Cold Spring Harbor perspectives in medicine

Hepatocellular carcinoma

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cold Spring Harbor perspectives in medicine - 02 Feb 2015

Buendia MA, Neuveut C

Link to Pubmed [PMID] – 25646384

Cold Spring Harb Perspect Med 2015 Feb;5(2):a021444

The hepatitis B virus (HBV) is a widespread human pathogen that causes liver inflammation, cirrhosis, and hepatocellular carcinoma (HCC). Recent sequencing technologies have refined our knowledge of the genomic landscape and pathogenesis of HCC, but the mechanisms by which HBV exerts its oncogenic role remain controversial. In a prevailing view, inflammation, liver damage, and regeneration may foster the accumulation of genetic and epigenetic defects leading to cancer onset. However, a more direct and specific contribution of the virus is supported by clinical and biological observations. Among genetically heterogeneous HCCs, HBV-related tumors display high genomic instability, which may be attributed to the ability of HBV to integrate its DNA into the host cell genome, provoking chromosomal alterations and insertional mutagenesis of cancer genes. The viral transactivator HBx may also participate in transformation by deregulating diverse cellular machineries. A better understanding of the complex mechanisms linking HBV to HCC will improve prevention and treatment strategies.

http://www.ncbi.nlm.nih.gov/pubmed/25646384