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© Research
Publication : Viruses

Hepatitis E in High-Income Countries: What Do We Know? And What Are the Knowledge Gaps?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Viruses - 25 May 2018

Capai L, Charrel R, Falchi A

Link to Pubmed [PMID] – 29799485

Link to DOI – 10.3390/v10060285

Viruses 2018 May; 10(6):

Hepatitis E virus (HEV) is a positive-strand RNA virus transmitted by the fecal⁻oral route. HEV genotypes 1 and 2 infect only humans and cause mainly waterborne outbreaks. HEV genotypes 3 and 4 are widely represented in the animal kingdom, and are mainly transmitted as a zoonosis. For the past 20 years, HEV infection has been considered an imported disease in developed countries, but now there is evidence that HEV is an underrecognized pathogen in high-income countries, and that the incidence of confirmed cases has been steadily increasing over the last decade. In this review, we describe current knowledge about the molecular biology of HEV, its clinical features, its main routes of transmission, and possible therapeutic strategies in developed countries.