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© Research
Publication : Research in microbiology

Genotoxicity of 2-nitro-7-methoxy-naphtho[2,1-b]furan (R7000): a case study with some considerations on nitrofurantoin and nifuroxazide

Team: Group: Infection, Genotoxicity and Cancer
Team: Archived: Helicobacter Pathogenesis
Member: Eliette Touati
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Research in microbiology - 01 Sep 2002

Hofnung M, Quillardet P, Michel V, Touati E

Link to Pubmed [PMID] – 12405349

Res. Microbiol. 2002 Sep;153(7):427-34

Two nitrofurans present broad-spectrum antimicrobial properties and some of them are used in human and veterinary medicine. Most of these molecules are mutagens and some of them were reported as carcinogens. Due to its extreme mutagenic potency in bacteria, the nitronaphtho derivative 2-nitro-7-methoxy-naphtho[2,1-b]furan (R7000) was used as a tool to analyze the mechanism of the genotoxic action of this family of chemicals. In the present paper, we review essential data on the genotoxicity of R7000 and briefly discuss the case of nitrofurantoin and nifuroxazide, two nitrofurans, still in use as urinary and gastrointestinal disinfectants.