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© Institut Pasteur
Cells infected for 24 hrs with C. Trachomatis. The cell nuclei are labelled in blue, the bacteria appear yellow, within the inclusion lumen. A bacterial protein secreted out the inclusion into the host cytoplasm id labelled in red.
Publication : Antimicrobial agents and chemotherapy

Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria

Team: Archived: Type II topoisomerases challenges
Team: Structural Microbiology
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 01 Aug 2006

Petrella S, Cambau E, Chauffour A, Andries K, Jarlier V, Sougakoff W

Link to Pubmed [PMID] – 16870785

Antimicrob. Agents Chemother. 2006 Aug;50(8):2853-6

The atpE gene encoding the subunit c of the ATP synthase of Mycobacterium tuberculosis, the target of the new diarylquinoline drug R207910, has been sequenced from in vitro mutants resistant to the drug. The previously reported mutation A63P and a new mutation, I66M, were found. The genetic diversity of atpE in 13 mycobacterial species was also investigated, revealing that the region involved in resistance to R207910 is conserved, except in Mycobacterium xenopi in which the highly conserved residue Ala63 is replaced by Met, a modification that may be associated with the natural resistance of M. xenopi to R207910.