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© Research
Publication : Developmental cell

Gene regulatory networks and transcriptional mechanisms that control myogenesis.

Team: Malaria Infection & Immunity
Team: Malaria Parasite Biology and Vaccines
Member: Margaret Buckingham
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Developmental cell - 10 Feb 2014

Buckingham M, Rigby PW

Link to Pubmed [PMID] – 24525185

Link to DOI – 10.1016/j.devcel.2013.12.020

Dev Cell 2014 Feb; 28(3): 225-38

We discuss the upstream regulators of myogenesis that lead to the activation of myogenic determination genes and subsequent differentiation, focusing on the mouse model. Key upstream genes, such as Pax3 and Pax7, Six1 and Six4, or Pitx2, participate in gene regulatory networks at different sites of skeletal muscle formation. MicroRNAs also intervene, with emerging evidence for the role of other noncoding RNAs. Myogenic determination and subsequent differentiation depend on members of the MyoD family. We discuss new insights into mechanisms underlying the transcriptional activity of these factors.