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© Research
Publication : Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie

Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity

Team: Archived: Nuclear Magnetic Resonance Of Biomolecules
Member: Alphonse Garcia
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie - 01 Jun 1997

Garcia A

Link to Pubmed [PMID] – 9247029

C. R. Acad. Sci. III, Sci. Vie 1997 Jun;320(6):505-8

CEM lymphoid cells expressing high levels of HIV-1 nef protein displayed a significant decrease in basal phosphatidyl-inositol 3-kinase (P13-kinase) activity associated with immunoprecipitates with anti-p85 regulatory subunit. In contrast, chronically infected U937 monocytic cells displayed a significant increase in basal P13-kinase activity in cells infected with HIV-1 nef compared to those infected with isogenic HIV-1 nef+. These findings suggest that HIV-1-nef expression is accompanied by a decrease in basal intracellular phosphatidyl-inositol 3-kinase activity and suggest that P13-kinase could be important for HIV-1 replication. Moreover, wortmannin, a potent in-vitro phosphatidyl-inositol 3-kinase inhibitor, can inhibit HIV-1 replication in U937 chronically infected cells. Together these results suggest a correlation between P13-kinase activity and HIV-1 replication.