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© Research
Publication : Medical mycology

Experimental murine model of disseminated infection by Saksenaea vasiformis: successful treatment with posaconazole

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Medical mycology - 29 Mar 2012

Salas V, Pastor FJ, Calvo E, Sutton D, García-Hermoso D, Mayayo E, Dromer F, Fothergill A, Alvarez E, Guarro J

Link to Pubmed [PMID] – 22458251

Med. Mycol. 2012 Oct;50(7):710-5

We have determined the in vitro activity of amphotericin B (AMB) and posaconazole (PSC) against Saksenaea vasiformis using broth microdilution and disk diffusion methods and determined the minimal fungicidal concentration (MFC). PSC was found to have the greatest in vitro activity in all cases and was the most efficacious in prolonging survival and reducing the fungal load in an immunocompetent murine model of disseminated infection caused by four strains of the fungus.