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© Research
Publication : Science (New York, N.Y.)

Evolutionary and somatic selection of the antibody repertoire in the mouse

Member: Ana Cumano
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 20 Nov 1987

Rajewsky K, Förster I, Cumano A

Link to Pubmed [PMID] – 3317826

Science 1987 Nov;238(4830):1088-94

The repertoire of antibody variable (V) regions has been subject to evolutionary selection, affecting both the diversity of V region genes in the germline and their expression in the B lymphocyte population and its subsets. In ontogeny, contact with an antigen leads to the expansion of B cells expressing antibodies complementary to it. In a defined phase of B cell differentiation, new sets of V regions are generated from the existing repertoire through somatic hypermutation. Cells carrying advantageous antibody mutants are selected into the memory compartment and produce a stable secondary response upon reexposure to the antigen.